“It’s a very, very dangerous situation,” Clinton said

Updated 6:38 PM ET

ISTANBUL Turkish artillery fired on Syrian targets after deadly shelling from Syria hit a Turkish border town on Wednesday, sharply raising tensions on a volatile border that has been crossed by tens of thousands of Syrian refugees fleeing violence in their country.

In a terse statement, the office of Turkey’s prime minister, Recep Tayyip Erdogan, condemned shelling that hit the Turkish town of Akcakale, 양주출장안마 killing five local residents and wounding a dozen others. The shelling appeared to come from Syrian government forces who were fighting Syrian rebels backed by Turkey, which has called for the ouster of Syrian President Bashar Assad.

“Our armed forces at the border region responded to this atrocious attack with artillery fire on points in Syria that were detected with radar, in line with the rules of engagement,” the Turkish statement said.

“Turkey, acting within the rules of engagement and international laws, will never leave unreciprocated such provocations by the Syrian regime against our national security,” it said.

Along the volatile border, a shell fired from inside Syria landed on a home in the Turkish village of Akcakale, killing a woman, her three daughters and another woman, and wounding at least 10 others, according to Turkish media.

Turkey’s NTV television said Turkish radar pinpointed the positions from where the shells were fired on Akcakale, and that those positions were hit.

“Turkey is a sovereign country. There was an attack on its territory. There must certainly be a response in international law. … I hope this is Syria’s last craziness. Syria will be called into account,” said Turkish Deputy Prime Minister Bulent Arinc.

Turkish media said Turkey has prepared a parliamentary bill for Syria that is similar to one that authorizes the Turkish military to intervene in northern Iraq in pursuit of Kurdish militants who have bases there. The bill is expected to be discussed in parliament on Thursday, Anadolu agency reported.

If approved, the bill could more easily open the way to unilateral action by Turkey’s armed forces inside Syria, without the involvement of its Western and Arab allies.

Secretary of State Hillary Rodham Clinton said the U.S. was “outraged that the Syrians have been shooting across the border,” adding that she would speak with Turkish Foreign Minister Ahmet Davutoglu on the matter.

“It’s a very, very dangerous situation,” Clinton said. “And all responsible nations need to band together to persuade the Assad regime to have a cease-fire, quit assaulting their own people and begin the process of a political transition.”

“This is yet another example of the depraved behavior of the Syrian regime, and why it must go,” said Pentagon press secretary George Little. “We regret the loss of life in Turkey, a strong ally, and continue to monitor the situation closely.”